Motivation: There is an ongoing search for definitive and reliable biomarkers to forecast or predict imminent seizure onset, but to date most research has been limited to EEG with sampling rates <1,000 Hz. High-frequency oscillations have gained acceptance as an indicator of epileptic tissue, but few have investigated the temporal properties of HFOs or their potential role as a predictor in seizure prediction. Here we evaluate time-varying trends in preictal HFO rates as a potential biomarker of seizure prediction.Methods: HFOs were (...) identified for all interictal and preictal periods with a validated automated detector in 27 patients who underwent intracranial EEG monitoring. We used LASSO logistic regression with several features of the HFO rate to distinguish preictal from interictal periods in each individual. We then tested these models with held-out data and evaluated their performance with the area-under-the-curve of their receiver-operating curve. Finally, we assessed the significance of these results using non-parametric statistical tests.Results: There was variability in the ability of HFOs to discern preictal from interictal states across our cohort. We identified a subset of 10 patients in whom the presence of the preictal state could be successfully predicted better than chance. For some of these individuals, average AUC in the held-out data reached higher than 0.80, which suggests that HFO rates can significantly differentiate preictal and interictal periods for certain patients.Significance: These findings show that temporal trends in HFO rate can predict the preictal state better than random chance in some individuals. Such promising results indicate that future prediction efforts would benefit from the inclusion of high-frequency information in their predictive models and technological architecture. (shrink)

Resisting Corporate Corruption teaches business ethics in a manner very different from the philosophical and legal frameworks that dominate graduate schools. The book offers twenty-eight case studies and nine essays that cover a full range of business practice, controls and ethics issues. The essays discuss the nature of sound financial controls, root causes of the Financial Crisis, and the evolving nature of whistleblower protections. The cases are framed to instruct students in early identification of ethics problems and how to work (...) such issues within corporate organizations. They also provide would-be whistleblowers with instruction on the challenges they’d face, plus information on the legal protections, and outside supports available should they embark on that course. Some of the cases illustrate how ‘The Young are the Most Vulnerable,’ i.e. short service employees are most at risk of being sacrificed by an unethical firm. Other cases show the ethical dilemmas facing well-known CEOs and the alternatives they can employ to better combine ethical conduct and sound business strategy. Through these case studies, students should emerge with a practical toolkit that better enables them to follow their moral compass. Finally, the cases provide an in depth look at how a corporation becomes progressively corrupted (Enron), how the Financial Crisis was rooted in ethical decay at institutions as diverse as Countrywide, Goldman Sacks, Citigroup, Fannie Mae and Moody’s, and at the ethical challenges that persist in the post-Crisis, post-Dodd-Frank environment. (shrink)

The analogy between sequences of behavior and sequences of words is examined in detail and found to be both logically and empirically defensible. Linguistic distinctions are shown to be applicable to other forms of behavior. A behavioral grammar framework is developed and applied to the study of conversational behavior. The framework is shown to be superior to simpler finite state, associative models and the formal limits of the latter are discussed.

In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. The need to develop new strategies in the fight against tuberculosis (TB) and related diseases has fuelled research into the evolutionary success of the M. tuberculosis complex members. Amongst the various disciplines, genomics and functional genomics have been instrumental in improving our understanding of these organisms. In this (...) review we will present some of the recent key findings on molecular determinants of mycobacterial pathogenicity and attenuation, the evolution of M. tuberculosis, genome dynamics, antigen mining for improved diagnostic and subunit antigens, and finally the identification of novel drug targets. The genomics revolution has changed the landscape of TB research, and now underpins our renewed efforts to defeat this deadly pathogen. (shrink)

This paper publishes a gold ring until recently in private hands in the United States. The former owners, private persons with no scholarly background, brought the ring to the present writer's attention upon learning that he had some knowledge of Greek inscriptions. The one deplorable fact is that this ring was removed from its context, so that much of its scientific value is forever lost to us. Nonetheless, the damage was done by others years ago, and its owners deserve praise (...) for making the ring available for study. The dedicatory inscription on it is an invaluable example of early Argive script. The details of acquisition are unclear. I have been able to ascertain only that the ring was acquired in ancient Mycenae from some Greeks who claimed to have dug it up in the area. As will be seen, in all probability it comes from the Argive Heraion. (shrink)

The fire beacon in the opening scenes of the Agamemnon commands attention and creates the positive image of light from darkness. In the immediate context the light of the beacon relieves the watchman of his toil and brings joy to Argos. The image, however, is not totally positive. The fire signal announces both the fall of Troy and the return of Agamemnon to Clytemnestra. The negative aspect, furthermore, is emphasised at the opening — the watchman's joy at seeing the beacon (...) gives way at line 36 to foreboding . For the original audience of 458 b.c. I suggest that this fire beacon proclaiming victory must have conveyed other negative overtones. In brief, it will have recalled to them vividly the signals used by the Persian commanders during the great invasion of 480 to announce Athens' capture to an expectant Persian court. (shrink)

Opioid use disorder rarely presents as a unitary psychiatric condition, and the comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which OUD can arise. These factors are heterogeneous and include genetic predisposition, exposure to prescription opioids, and environmental risks. Crucially, one key environmental risk factor for OUD is early life adversity. OUD and other substance use disorders are widely considered to derive in part from abnormal reward circuit function, which is likely also implicated in comorbid mental (...) illnesses such as depression, bipolar disorder, and schizophrenia. ELA may disrupt reward circuit development and function in a manner predisposing to these disorders. Here, we describe new findings addressing the effects of ELA on reward circuitry that lead to OUD and comorbid disorders, potentially via shared neural mechanisms. We discuss some of these OUD-related problems in both humans and animals. We also highlight the increasingly apparent, crucial contribution of biological sex in mediating the range of ELA-induced disruptions of reward circuitry which may confer risk for the development of OUD and comorbid neuropsychiatric disorders. (shrink)

For quite some time, cognitive science has offered philosophy an opportunity to address central problems with an arsenal of relevant theories and empirical data. However, even among those naturalistically inclined, it has been hard to find a universally accepted way to do so. In this article, we offer a case study of how cognitive-science input can elucidate an epistemological issue that has caused extensive debate. We explore Jason Stanley’s idea of the practical grasp of a propositional truth and present naturalistic (...) arguments against his reductive approach to knowledge. We argue that a plausible interpretation of cognitive-science input concerning knowledge—even if one accepts that knowledge how is partly propositional—must involve an element of knowing how to act correctly upon the proposition; and this element of knowing how to act correctly cannot itself be propositional. (shrink)

For several centuries, the Russians have been famous for the number of transactions they conduct through unofficial channels. This book, the first sustained attempt to explain and analyze Russian society's reliance on unofficial "give-and-take," focuses especially on two key practices: bribery (the use of public office for private gain) and blat (the informal exchange of favors). It brings together specialists from a wide range of disciplines.

We defend two theses: (1) Knowledge how and knowledge that are two distinct forms of knowledge, and; (2) Stanley-style intellectualism is neuro-psychologically implausible. Our naturalistic argument for the distinction between knowledge how and knowledge that is based on a consideration of the nature of slips and basic activities. We further argue that Stanley’s brand of intellectualism has certain ontological consequences that go against modern cognitive neuroscience and psychology. We tie up our line of thought by showing that input from cognitive (...) neuroscience and psychology, on multiple levels of analysis, cohere in supporting the distinction between two separate forms of knowledge. The upshot is a neuro-psychologically plausible understanding of knowledge. (shrink)

This paper draws from the fields of history, sociology, psychology, moral philosophy, and organizational theory to establish a theoretical connection between a social/organizational influence (ethical work climate) and an individual cognitive element of moral behavior (moral awareness). The research was designed to help to fill a gap in the existing literature by providing empirical evidence of the connection between organizational influences and individual moral awareness and subsequent ethical choices, which has heretofore largely been merely assumed. Results of the study provide (...) evidence that ethical work climate (EWC) is a primary predictor of individual moral awareness, and that the influence of social factors often overrides the effects of individual differences in a work group setting. Implications for future research are provided. (shrink)

For any choice of initial state and weak assumptions about the Hamiltonian, large isolated quantum systems undergoing Schrödinger evolution spend most of their time in macroscopic superposition states. The result follows from von Neumann’s 1929 Quantum Ergodic Theorem. As a specific example, we consider a box containing a solid ball and some gas molecules. Regardless of the initial state, the system will evolve into a quantum superposition of states with the ball in macroscopically different positions. Thus, despite their seeming fragility, (...) macroscopic superposition states are ubiquitous consequences of quantum evolution. We discuss the connection to many worlds quantum mechanics. (shrink)

Since at least Hume and Kant, philosophers working on the nature of aesthetic judgment have generally agreed that common sense does not treat aesthetic judgments in the same way as typical expressions of subjective preferences—rather, it endows them with intersubjective validity, the property of being right or wrong regardless of disagreement. Moreover, this apparent intersubjective validity has been taken to constitute one of the main explananda for philosophical accounts of aesthetic judgment. But is it really the case that most people (...) spontaneously treat aesthetic judgments as having intersubjective validity? In this paper, we report the results of a cross‐cultural study with over 2,000 respondents spanning 19 countries. Despite significant geographical variations, these results suggest that most people do not treat their own aesthetic judgments as having intersubjective validity. We conclude by discussing the implications of our findings for theories of aesthetic judgment and the purpose of aesthetics in general. (shrink)

The choroid plexuses (CPs) are involved in the most-basic aspects of neural function including maintaining the extracellular milieu of the brain by actively modulating chemical exchange between the CSF and brain parenchyma, surveying the chemical and immunological status of the brain, detoxifying the brain, secreting a nutritive “cocktail” of polypeptides and participating in repair processes following trauma. This diversity of functions may mean that even modest changes in the CP can have far-reaching effects. Indeed, changes in the anatomy and physiology (...) of the CP have been linked to aging and several CNS diseases. It is also possible that replacing diseased or transplanting healthy CP might be useful for treating acute and chronic brain diseases. This review focuses on the wide-ranging and under-appreciated functions of the CP, alterations of these functions in aging and neurodegeneration, and recent demonstrations of the therapeutic potential of transplanted CP for neural trauma. BioEssays 27:262–274, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Christian miller invites further clarification about the relationship between accountability and autonomy. Whereas embracing accountability to others for one’s responsibilities in those relationships emphasizes relationality, autonomy accents the individual’s own capacities to exhibit agency in enacting one’s decisions. Accordingly, we theorize that relational capacities for empathic concern and perspective-taking are especially important in the virtue of accountability. The capacity for self-regulation may serve both one’s autonomous pursuits and accountability for carrying out one’s responsibilities...

We share with Anderson & Lebiere (A&L) (and with Newell before them) the goal of developing a domain-general framework for modeling cognition, and we take seriously the issue of evaluation criteria. We advocate a more focused approach than the one reflected in Newell's criteria, based on analysis of failures as well as successes of models brought into close contact with experimental data. A&L attribute the shortcomings of our parallel-distributed processing framework to a failure to acknowledge a symbolic level of thought. (...) Our framework does acknowledge a symbolic level, contrary to their claim. What we deny is that the symbolic level is the level at which the principles of cognitive processing should be formulated. Models cast at a symbolic level are sometimes useful as high-level approximations of the underlying mechanisms of thought. The adequacy of this approximation will continue to increase as symbolic modelers continue to incorporate principles of parallel distributed processing. (shrink)

I offer a new theory of faultless disagreement, according to which truth is absolute (non-relative) but can still be non-objective. What's relative is truth-aptness: a sentence like ‘Vegemite is tasty’ (V) can be truth-accessible and bivalent in one context but not in another. Within a context in which V fails to be bivalent, we can affirm that there is no issue of truth or falsity about V, still disputants, affirming and denying V, were not at fault, since, in their context (...) of assertion V was bivalent. This theory requires a theory of assertion that is a form of cognitive expressivism. (shrink)

In its comprehensive overview of Alain Locke's pragmatist philosophy this book captures the radical implications of Locke's approach within pragmatism, the critical temper embedded in Locke's works, the central role of power and empowerment of the oppressed and the concept of broad democracy Locke employed.

We can share experiences with a person online, but the experiences seem thin when compared with face-to-face experiences. Online adventures (social networking, gaming) can certainly strengthen friendship bonds that were forged in more embodied interactions, but can they create those bonds? The kind of presence required for deep friendship does not seem cultivated in many online interactions. Presence in friendship requires “being with” and “doing for” (sacrifice). The forms of “being with” and “doing for” on social networking sites (or even (...) in interactive gaming) seem trivial because the stakes are very low. More important, the “shared space” of digital life is disembodied space. We cannot really touch one another, smell one another, detect facial expressions or moods, and so on. Real bonding is more biological than psychological and requires physical contact. The emotional entanglement of real friendship produces oxytocin and endorphins in the brains and bodies of friends — cementing them together in ways that are more profound than other relationships. -/- It is possible that virtual reality and augmented reality technology will soon be able to generate such friendship-forming experiences. Having embodied adventures with another person — even in a V.R. suit — is more likely to trigger the deeper oxytocin-based bonding. Current social networking, however, seems to privilege the shallow triggers of the brain’s reward system (dopamine squirts in the ventral tegumental area). (shrink)

v. 1. The collective use and evolution of concepts.

Section IV of the First Piece of Religion accomplishes the first major task of Immanuel Kant's first experiment by explaining what bare reason justifies us to say about the essential condition of human nature. The second half of Section IV fulfils the corresponding mandate of Kant's second experiment by assessing how closely the traditional Christian understanding of evil conforms to this rational standard. After examining these two aspects of his conclusion, this chapter demonstrates how the bulk of Kant's “General Comment”‐the (...) portion that was labeled “Section V” in R1 previews his subsequent argument that a true religion is one that empowers us to overcome the problem that evil poses for human nature. This basic precept of Kantian religion is: ignorance of the exact method God may have of making up for our moral deficiencies is not only acceptable, but “unavoidable”. (shrink)

Punishment and Reparations are sometimes held to express retaliatory emotions whose object is to strike back against a victimizer. I begin by examining a version of this idea in Mill's writings about natural resentment and the sense of justice in Chapter V of Utilitarianism. Mill's view is that the ?natural? sentiment of resentment or ?vengeance? that is at the heart of the concept of justice is essentially retaliatory, therefore has ?nothing moral in it,? and so must be disciplined or moralized (...) from without by the desire to promote the general welfare. I argue to the contrary that if ?reactive attitudes? like resentment and moral blame are understood as Strawson analyzed them, as essentially ?interpersonal? or ?second personal?, they have a different content and function. They implicitly demand respect in a way that also expresses respect for the victimizer as a member of mutually accountable community of moral equals. Some implications of this idea are discussed for the ?expressive theory of punishment? and ?civil recourse? theories of torts. (shrink)

The field of neuroimaging has reached a watershed. Brain imaging research has been the source of many advances in cognitive neuroscience and cognitive science over the last decade, but recent critiques and emerging trends are raising foundational issues of methodology, measurement, and theory. Indeed, concerns over interpretation of brain maps have created serious controversies in social neuroscience, and, more important, point to a larger set of issues that lie at the heart of the entire brain mapping enterprise. In this volume, (...) leading scholars -- neuroimagers and philosophers of mind -- reexamine these central issues and explore current controversies that have arisen in cognitive science, cognitive neuroscience, computer science, and signal processing. The contributors address both statistical and dynamical analysis and modeling of neuroimaging data and interpretation, discussing localization, modularity, and neuroimagers' tacit assumptions about how these two phenomena are related; controversies over correlation of fMRI data and social attributions ; and the standard inferential design approach in neuroimaging. Finally, the contributors take a more philosophical perspective, considering the nature of measurement in brain imaging, and offer a framework for novel neuroimaging data structures. Contributors: William Bechtel, Bharat Biswal, Matthew Brett, Martin Bunzl, Max Coltheart, Karl J. Friston, Joy J. Geng, Clark Glymour, Kalanit Grill-Spector, Stephen José Hanson, Trevor Harley, Gilbert Harman, James V. Haxby, Rik N. Henson, Nancy Kanwisher, Colin Klein, Richard Loosemore, Sébastien Meriaux, Chris Mole, Jeanette A. Mumford, Russell A. Poldrack, Jean-Baptiste Poline, Richard C. Richardson, Alexis Roche, Adina L. Roskies, Pia Rotshtein, Rebecca Saxe, Philipp Sterzer, Bertrand Thirion, Edward Vul The hardcover edition does not include a dust jacket. (shrink)

A comprehensive, in-depth study of Roe v. Wade and Doe v. Bolton, the 1973 U.S. Supreme Court decisions which legalized abortion. The author closely analyzes the opinions, and contends that the Court made significant errors in its understanding of the many aspects surrounding abortion.

I argue that Leibniz's treatment of void or empty space in the appendix to his fourth letter to Clarke conflicts with the way he elsewhere treats (metaphysical) evil, insofar as he allows that God has created a world with the one kind of privation (evil), while insisting that God would not have created a world with the other kind of privation (void). I consider three respects in which the moral case might be thought to differ relevantly from the physical one, (...) and argue that none of them succeed in removing the inconsistency. Rather than denying the existence of void, Leibniz should have been led by his treatment of evil to realize that the arguments he deploys in this appendix are dubious, and that the principles to which he appeals do not rule out empty space any more than they rule out evil, darkness, cold, or any other privations. (shrink)

Geoengineering – roughly “the intentional manipulation of the planetary systems at a global scale” (Keith 2000) – to combat climate change is often introduced as a “plan B”: an alternative solution in case “plan A”, reducing emissions, fails. This framing is typically deployed as part of an argument that research and development is necessary in case robust conventional mitigation is not forthcoming, or proves insufficient to prevent dangerous climate impacts. Since coming to prominence with the release of the Royal Society (...) report in 2009 (Shepherd et al. 2009, v), the Plan B framing has proved popular with scientists, in policy circles, and in the news media (see Nerlich and Jaspal 2012; Luokkanen, Huttunen, and Hilden 2014). Though sometimes used to refer to geoengineering as a whole, it is associated particularly strongly with stratospheric sulfate injection (SSI) techniques. Consequently, these will be our focus here. We argue that the plan B framing is particularly ill-suited to the integrative assessment of options within climate policy, because it oversimplifies a complex issue in a misleading and deceptive way. For instance, it highlights extreme positions, presents SSI as an alternative independent from mainstream policies, ignores the multiplicity of options available, and neglects threats of morally indecent SSI in a context of ongoing political inertia. We are particularly concerned about the way ‘Plan B’ risks conveying an implicit hyper-optimism about SSI, and so obscures the need for ethical standards. (shrink)

MARXISM AND THE PHILOSOPHY, OF LANGUAGE By V.N. Volo?inov translated by Ladislav Matejka & I.R. Titunik Cambridge, Mass.: Harvard University Press, 1986. 205 pp., $9.95 The contributions of Volo?inov's theories of language are assessed and are contrasted to traditional Marxist philosophy, Saussurean linguistics and more recent developments in transformational grammar and sociolinguistics. Studying connections between language and politics in the 1920s, Volosinov explored the ways social reality enters verbal signs and their usage, anticipating many of the debates within modem linguistics.

Recent accounts of pretense have been underdescribed in a number of ways. In this paper, we present a much more explicit cognitive account of pretense. We begin by describing a number of real examples of pretense in children and adults. These examples bring out several features of pretense that any adequate theory of pretense must accommodate, and we use these features to develop our theory of pretense. On our theory, pretense representations are contained in a separate mental workspace, a Possible (...) World Box which is part of the basic architecture of the human mind. The representations in the Possible World Box can have the same content as beliefs. Indeed, we suggest that pretense representations are in the same representational ``code'' as beliefs and that the representations in the Possible World Box are processed by the same inference and UpDating mechanisms that operate over real beliefs. Our model also posits a Script Elaborator which is implicated in the embellishment that occurs in pretense. Finally, we claim that the behavior that is seen in pretend play is motivated not from a ``pretend desire'', but from a real desire to act in a way that ®ts the description being constructed in the Possible World Box. We maintain that this account can accommodate the central features of pretense exhibited in the examples of pretense, and we argue that the alternative accounts either can't accommodate or fail to address entirely some of the central features of pretense. q 2000 Elsevier Science B.V. All rights reserved. (shrink)

Modalities enter into practically every area of contemporary philosophy. Great progress has been made in understanding the variety of differences between what is possible, what is actual, and what is necessary. But things were not always so clear. We owe a great debt in this area, as in so many others, to Aristotle, who had a lot to say on the topic, part of which comprises his discussion and use of the actuality/potentiality distinction. One important task in understanding his discussion (...) of actuality and potentiality is locating the distinction within the wider area of modality in general. One very general area in which modalities are significant is the assessment of arguments. Aristotle provides us with the basics of a modal logic, and in Metaphysics V 12, treats the family of modal notions expressed by the Greek noun dunamis and its cognates. This article explores his account of energeia and dunamis, matter and substance, capacities, natures, and dispositions. (shrink)

_CONTENTS:__ Introduction Selected Bibliography Five Sermons:_ The Preface_ Sermon I - Upon Human Nature Sermon II - Upon Human Nature Sermon III - Upon Human Nature Sermon IV - Upon The Love Of Our Neighbor Sermon V - Upon The Love Of Our Neighbor A dissertation upon the Nature of Virtue_.